Breakthrough Research at Jinan University: Dynamic Smart Coating Technology Solves Long-Term Implantation Challenges of Medical Silicone Rubber-Iota

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News > Dynamic industry > Breakthrough Research at Jinan University: Dynamic Smart Coating Technology Solves Long-Term Implantation Challenges of Medical Silicone Rubber

Breakthrough Research at Jinan University: Dynamic Smart Coating Technology Solves Long-Term Implantation Challenges of Medical Silicone Rubber

Silicone rubber, widely used as a clinical implant material, serves extensively in artificial joints, heart valves, breast implants, and other fields due to its excellent mechanical properties and biocompatibility. However, its surface is prone to adhesion by proteins, bacteria, and cells, which can lead to chronic inflammation, infection, and even implant failure. This bottleneck issue has long limited further applications of silicone rubber. Traditional modification methods such as polyester coatings degrade easily, and hydrogel coatings have poor mechanical stability, making long-lasting anti-adhesion difficult to achieve. Recently, the Biomedical Engineering Research Team at Jinan University proposed a disruptive technology—a zwitterionic-modified polyrotaxane strategy—that brings a revolutionary breakthrough to the field of medical materials.

From “Passive Defense” to “Active Defense”: Dual Mechanisms Build an Intelligent Barrier

The research team innovatively combined two core mechanisms to create a dynamic surface coating with both long-lasting anti-adhesion and stress-responsive capabilities:

The “Hydrated Shield” of Zwitterionic Polymers

A dense hydrated layer formed by balanced positive and negative charges constructs a physical barrier on the material surface, effectively blocking nonspecific adhesion of proteins, bacteria, and cells, thus fundamentally reducing biological contamination risks.

The “Molecular Slide Rail” of the Polyrotaxane Dynamic Network

The unique “axle-ring” structure of polyrotaxane grants the polymer chains the ability to freely slide along the axle. When external environmental changes occur (such as mechanical stress or temperature fluctuations), the coating actively adjusts its surface morphology, rapidly restoring anti-adhesion performance, achieving a dynamic defense that “gets stronger under stress.”

From Laboratory to Clinic: Performance Verification Highlights Technological Advantages

In long-term experiments simulating the human body environment, this modified coating demonstrated significant advantages:

90% Improvement in Anti-Adhesion Performance: Protein adsorption and bacterial proliferation decreased by an order of magnitude compared to traditional materials;
Breakthrough in Mechanical Stability: After 100,000 friction cycles, the coating structure remained intact, and the hydrated layer was undamaged;
Stress Response Speed at Millisecond Level: Under simulated pulsatile blood vessel pressure, the coating surface rapidly reconstructed, maintaining continuous protection.